Proper Storage and Handling of Lyophilized Peptides

What Lyophilization Does

Lyophilization, or freeze-drying, removes water from a peptide sample under vacuum, leaving behind a stable, powder-like form. This process significantly extends shelf life compared to storing a peptide in liquid solution.

Temperature Considerations

Lyophilized peptides are generally more stable than reconstituted ones, but temperature still matters. Many peptides are recommended to be stored in a freezer for long-term storage, with short-term storage at refrigerated temperatures often acceptable depending on the specific peptide.

Protecting Against Moisture and Light

Because lyophilized peptides are hygroscopic, meaning they readily absorb moisture from the air, keeping vials sealed and using desiccants during storage helps preserve stability. Some peptides are also light-sensitive, so storing vials away from direct light is a reasonable precaution.

Handling During Transfer

When moving lyophilized peptide vials between storage locations, minimizing temperature fluctuations and avoiding repeated freeze-thaw cycles for any reconstituted portion helps maintain sample integrity over time.

Labeling and Tracking

Clear labeling with batch number, receipt date, and storage conditions helps maintain an accurate inventory and makes it easier to track a sample’s history, which supports good laboratory record-keeping practices overall.